InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Txndc8

Summary

InnateDB Protein

IDBP-150045.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Txndc8

Protein Name

thioredoxin domain containing 8

Synonyms

4930429J24Rik; Sptrx-3; Sptrx3; Trx6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099961

InnateDB Gene

IDBG-150043 (Txndc8)

Protein Structure

UniProt Annotation

Function

May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15181017}. Golgi apparatus {ECO:0000269PubMed:15181017}.

Disease Associations

Tissue Specificity

Testis-specific. Only expressed during spermiogenesis, prominently in the Golgi apparatus of pachytene spermatocytes and round and elongated spermatids, with a transient localization in the developing acrosome of round spermatids (at protein level). {ECO:0000269PubMed:15181017}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015035	protein disulfide oxidoreductase activity
GO:0016209	antioxidant activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0001675	acrosome assembly
GO:0006662	glycerol ether metabolic process
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0045454	cell redox homeostasis
GO:0055114	oxidation-reduction process