InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adam24

Summary

InnateDB Protein

IDBP-150059.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adam24

Protein Name

a disintegrin and metallopeptidase domain 24 (testase 1)

Synonyms

Dtgn5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050727

InnateDB Gene

IDBG-150057 (Adam24)

Protein Structure

UniProt Annotation

Function

Plasma membrane protease present on mature sperm that may be involved in sperm function during epididymal maturation and/or fertilization.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed exclusively in testis and more specifically on the surface of mature sperm. Localized to the equatorial region of the plasma membrane of cauda epididymal sperm.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0030154	cell differentiation
GO:0060468	prevention of polyspermy

Cellular Component

GO:0005575	cellular_component
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:105984

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR001762 Blood coagulation inhibitor, Disintegrin
IPR002870 Peptidase M12B, propeptide
IPR006586 ADAM, cysteine-rich

PFAM

PF00008
PF01421
PF00200
PF01562
PF08516

PRINTS

PR00289

PIRSF

SMART

SM00181
SM00050
SM00608

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt