Version 5.4
Mus musculus Protein: Robo4
Summary
InnateDB Protein IDBP-150095.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Robo4
Protein Name roundabout homolog 4 (Drosophila)
Synonyms 1200012D01Rik; AI593217;
Species Mus musculus
Ensembl Protein ENSMUSP00000099959
InnateDB Gene IDBG-150093 (Robo4)
Protein Structure
UniProt Annotation
Function Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins. {ECO:0000269PubMed:12941633}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed specifically in embryo and adult vascular endothelium. {ECO:0000269PubMed:12941633}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0030154 cell differentiation
GO:0030336 negative regulation of cell migration
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1921394
InterPro IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin
PFAM PF00041
PF01108
PF07679
PF00047
PRINTS
PIRSF
SMART SM00408
SM00409
SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8C310
PhosphoSite PhosphoSite-Q8C310
TrEMBL
UniProt Splice Variant
Entrez Gene 74144
UniGene Mm.485070
RefSeq NP_083059
MGI ID
MGI Symbol Robo4
OMIM
CCDS CCDS22977
HPRD
IMGT
EMBL AF536772 AK004723 AK087355 BC020129
GenPept AAH20129 AAQ10749 BAB23506 BAC39850

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca