InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adcyap1r1

Summary

InnateDB Protein

IDBP-150152.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adcyap1r1

Protein Name

adenylate cyclase activating polypeptide 1 receptor 1

Synonyms

2900024I10Rik; AI846590; PAC1; PAC1R; PACAP1-R;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000063784

InnateDB Gene

IDBG-150150 (Adcyap1r1)

Protein Structure

UniProt Annotation

Function

This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004999	vasoactive intestinal polypeptide receptor activity
GO:0005515	protein binding
GO:0008179	adenylate cyclase binding
GO:0030306	ADP-ribosylation factor binding
GO:0042923	neuropeptide binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007283	spermatogenesis
GO:0010524	positive regulation of calcium ion transport into cytosol
GO:0019933	cAMP-mediated signaling
GO:0030154	cell differentiation
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0032355	response to estradiol
GO:0033555	multicellular organismal response to stress
GO:0042493	response to drug
GO:0045471	response to ethanol
GO:0046545	development of primary female sexual characteristics
GO:0060548	negative regulation of cell death
GO:0060732	positive regulation of inositol phosphate biosynthetic process

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005791	rough endoplasmic reticulum
GO:0005901	caveola
GO:0005923	tight junction
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043005	neuron projection
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

MGI:108449

InterPro

IPR000832 GPCR, family 2, secretin-like
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR002285 GPCR, family 2, pituitary adenylate cyclase activating polypeptide type 1 receptor
IPR017981 GPCR, family 2-like

PFAM

PF00002
PF02793

PRINTS

PR00249
PR01156

PIRSF

SMART

SM00008

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt