InnateDB Protein
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IDBP-150176.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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2300005B03Rik
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Protein Name
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RIKEN cDNA 2300005B03 gene
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Synonyms
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SLURP-2; Slurp2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000051457
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InnateDB Gene
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IDBG-150174 (2300005B03Rik)
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Protein Structure
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Function |
Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). Isoform 2 modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha(4)beta(2) nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha(4)beta(2) nAChRs. Prevents plasticity in the primary visual cortex late in life. In keratinocytes, isoform 3 delays differentiation and prevents apoptosis (By similarity). {ECO:0000250}.
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Subcellular Localization |
Isoform 1: Secreted {ECO:0000305}.Isoform 2: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}. Cell projection, dendrite. Note=Detected in Purkinje cells soma and proximal dendrites.Isoform 3: Secreted {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Isoform 2 is expressed in neurons of multiple regions in the CNS, including the cerebral cortex, thalamus, substantia nigra, cerebellum, amygdala and hippocampus. Also expressed in kidney, heart and thymus, but at lower levels than in the brain. Expressed in the primary visual cortex (V1) and the lateral geniculate nucleus (at protein level). Isoform 3 is widely expressed, including in dendritic cells, macrophages, B- and T- lymphocytes. {ECO:0000269PubMed:10402197, ECO:0000269PubMed:11906696, ECO:0000269PubMed:21071629}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1916712
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InterPro |
IPR001526
CD59 antigen
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PFAM |
PF00021
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9WVC2
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
69462
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UniGene |
Mm.64338
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RefSeq |
NP_001075430
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MGI ID |
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MGI Symbol |
2300005B03Rik
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OMIM |
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CCDS |
CCDS37103
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HPRD |
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IMGT |
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EMBL |
AB272582
AC118022
AF141377
AF169202
AK013827
AK161907
AK162920
AK165295
AK165314
BC037541
BC115610
BC115611
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GenPept |
AAD38939
AAF16899
AAH37541
AAI15611
AAI15612
BAB29006
BAE36629
BAE37115
BAE38124
BAE38132
BAF48397
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