InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lynx1

Summary

InnateDB Protein

IDBP-150197.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lynx1

Protein Name

Ly6/neurotoxin 1

Synonyms

AI838844; SLURP-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023259

InnateDB Gene

IDBG-150195 (Lynx1)

Protein Structure

UniProt Annotation

Function

Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). Isoform 2 modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha(4)beta(2) nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha(4)beta(2) nAChRs. Prevents plasticity in the primary visual cortex late in life. In keratinocytes, isoform 3 delays differentiation and prevents apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Isoform 1: Secreted {ECO:0000305}.Isoform 2: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}. Cell projection, dendrite. Note=Detected in Purkinje cells soma and proximal dendrites.Isoform 3: Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 2 is expressed in neurons of multiple regions in the CNS, including the cerebral cortex, thalamus, substantia nigra, cerebellum, amygdala and hippocampus. Also expressed in kidney, heart and thymus, but at lower levels than in the brain. Expressed in the primary visual cortex (V1) and the lateral geniculate nucleus (at protein level). Isoform 3 is widely expressed, including in dendritic cells, macrophages, B- and T- lymphocytes. {ECO:0000269PubMed:10402197, ECO:0000269PubMed:11906696, ECO:0000269PubMed:21071629}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.