InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ercc1

Summary

InnateDB Protein

IDBP-150203.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ercc1

Protein Name

excision repair cross-complementing rodent repair deficiency, complementation group 1

Synonyms

Ercc-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003645

InnateDB Gene

IDBG-150201 (Ercc1)

Protein Structure

UniProt Annotation

Function

Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000014	single-stranded DNA endodeoxyribonuclease activity
GO:0001094	TFIID-class transcription factor binding
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003697	single-stranded DNA binding
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0017025	TBP-class protein binding
GO:0019904	protein domain specific binding
GO:0043566	structure-specific DNA binding

Biological Process

GO:0000720	pyrimidine dimer repair by nucleotide-excision repair
GO:0000737	DNA catabolic process, endonucleolytic
GO:0001302	replicative cell aging
GO:0006281	DNA repair
GO:0006289	nucleotide-excision repair
GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006302	double-strand break repair
GO:0006310	DNA recombination
GO:0006312	mitotic recombination
GO:0006949	syncytium formation
GO:0006974	cellular response to DNA damage stimulus
GO:0006979	response to oxidative stress
GO:0007281	germ cell development
GO:0007283	spermatogenesis
GO:0007584	response to nutrient
GO:0008283	cell proliferation
GO:0008584	male gonad development
GO:0009650	UV protection
GO:0009744	response to sucrose stimulus
GO:0010165	response to X-ray
GO:0010259	multicellular organismal aging
GO:0032205	negative regulation of telomere maintenance
GO:0035166	post-embryonic hemopoiesis
GO:0035264	multicellular organism growth
GO:0036297	interstrand cross-link repair
GO:0045190	isotype switching
GO:0048468	cell development
GO:0048477	oogenesis
GO:0048568	embryonic organ development
GO:0051276	chromosome organization

Cellular Component

GO:0000109	nucleotide-excision repair complex
GO:0000784	nuclear chromosome, telomeric region
GO:0005634	nucleus
GO:0005669	transcription factor TFIID complex
GO:0005737	cytoplasm