InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Leprel1

Summary

InnateDB Protein

IDBP-150279.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Leprel1

Protein Name

leprecan-like 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038056

InnateDB Gene

IDBG-150277 (Leprel1)

Protein Structure

UniProt Annotation

Function

Shows prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types II, IV and V. {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum. Golgi apparatus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0019797	procollagen-proline 3-dioxygenase activity
GO:0031418	L-ascorbic acid binding

Biological Process

GO:0008285	negative regulation of cell proliferation
GO:0019511	peptidyl-proline hydroxylation
GO:0032963	collagen metabolic process
GO:0055114	oxidation-reduction process