Version 5.4
Mus musculus Protein: Cd3eap
Summary
InnateDB Protein IDBP-150291.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd3eap
Protein Name CD3E antigen, epsilon polypeptide associated protein
Synonyms 1190028F09; 2610103M17Rik; ASE-1; Ase1; CAST; PAF49;
Species Mus musculus
Ensembl Protein ENSMUSP00000044653
InnateDB Gene IDBG-150289 (Cd3eap)
Protein Structure
UniProt Annotation
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Involved in UBTF-activated transcription, presumably at a step following PIC formation. {ECO:0000269PubMed:15226435}.
Subcellular Localization Nucleus, nucleolus {ECO:0000269PubMed:15226435}. Note=Accumulates in the nucleolus of exponentially growing cells.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0009303 rRNA transcription
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005736 DNA-directed RNA polymerase I complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID MGI:1917583
InterPro IPR013240 DNA-directed RNA polymerase I, subunit RPA34.5
PFAM PF08208
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q76KJ5
PhosphoSite PhosphoSite-Q76KJ5
TrEMBL
UniProt Splice Variant
Entrez Gene 70333
UniGene Mm.171370
RefSeq NP_665821
MGI ID
MGI Symbol Cd3eap
OMIM
CCDS CCDS39798
HPRD
IMGT
EMBL AB091121 BC029206 BC071199
GenPept AAH29206 AAH71199 BAD02839

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca