InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd74

Summary

InnateDB Protein

IDBP-150306.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd74

Protein Name

CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)

Synonyms

CLIP; DHLAG; HLADG; Ia-GAMMA; Ii;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095171

InnateDB Gene

IDBG-150302 (Cd74)

Protein Structure

UniProt Annotation

Function

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0004896	cytokine receptor activity
GO:0005515	protein binding
GO:0019955	cytokine binding
GO:0023026	MHC class II protein complex binding
GO:0035718	macrophage migration inhibitory factor binding
GO:0042289	MHC class II protein binding
GO:0042658	MHC class II protein binding, via antigen binding groove
GO:0044183	protein binding involved in protein folding
GO:0050998	nitric-oxide synthase binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001516	prostaglandin biosynthetic process
GO:0001961	positive regulation of cytokine-mediated signaling pathway
GO:0002606	positive regulation of dendritic cell antigen processing and presentation
GO:0002792	negative regulation of peptide secretion
GO:0002821	positive regulation of adaptive immune response
GO:0002830	positive regulation of type 2 immune response
GO:0002906	negative regulation of mature B cell apoptotic process
GO:0006461	protein complex assembly
GO:0006886	intracellular protein transport
GO:0006952	defense response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0008283	cell proliferation
GO:0016064	immunoglobulin mediated immune response
GO:0019882	antigen processing and presentation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030890	positive regulation of B cell proliferation
GO:0035691	macrophage migration inhibitory factor signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045059	positive thymic T cell selection
GO:0045060	negative thymic T cell selection
GO:0045089	positive regulation of innate immune response
GO:0045581	negative regulation of T cell differentiation
GO:0045582	positive regulation of T cell differentiation
GO:0048146	positive regulation of fibroblast proliferation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051085	chaperone mediated protein folding requiring cofactor
GO:0060907	positive regulation of macrophage cytokine production
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090023	positive regulation of neutrophil chemotaxis
GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production

Cellular Component

GO:0005764	lysosome
GO:0005770	late endosome
GO:0005771	multivesicular body
GO:0005773	vacuole
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0035692	macrophage migration inhibitory factor receptor complex
GO:0035693	NOS2-CD74 complex
GO:0042613	MHC class II protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:96534

InterPro

IPR000716 Thyroglobulin type-1
IPR011988 MHC class II-associated invariant chain, trimerisation
IPR015386 MHC class II-associated invariant chain/CLIP, MHC II-interacting
IPR022339 MHC class II-associated invariant chain

PFAM

PF00086
PF08831
PF09307

PRINTS

PR01990

PIRSF

PIRSF001992

SMART

SM00211

TIGRFAMs

Post-translational Modifications

Modification

Cross-References