InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppp1r13l

Summary

InnateDB Protein

IDBP-150321.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppp1r13l

Protein Name

protein phosphatase 1, regulatory (inhibitor) subunit 13 like

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047839

InnateDB Gene

IDBG-150319 (Ppp1r13l)

Protein Structure

UniProt Annotation

Function

Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (By similarity). {ECO:0000250UniProtKB:Q8WUF5}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic but also nuclear. {ECO:0000250}.

Disease Associations

Note=Defects in Ppp1r13l are the cause of the waved 3 phenotype, a recessive mutation characterized by abnormalities of the heart and skin. Affected animals have open eyes at birth and hair abnormalities. They develop focal cardiac necrosis at an early age which progresses to fatal dilated cardiomyopathy. This is due to a 14-bp deletion which gives rise to a truncated protein. {ECO:0000269PubMed:15661756}.

Tissue Specificity

Most abundant in skin with high levels also found in heart, testis and stomach. In E15.5 embryonic heart, expressed at higher levels in atria than ventricles. {ECO:0000269PubMed:15661756}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0042802	identical protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0003215	cardiac right ventricle morphogenesis
GO:0003229	ventricular cardiac muscle tissue development
GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0009791	post-embryonic development
GO:0031076	embryonic camera-type eye development
GO:0035264	multicellular organism growth
GO:0042633	hair cycle
GO:0048871	multicellular organismal homeostasis
GO:0060048	cardiac muscle contraction