Mus musculus Protein: Gprc6a | |||||||
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Summary | |||||||
InnateDB Protein | IDBP-150349.6 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | Gprc6a | ||||||
Protein Name | G protein-coupled receptor, family C, group 6, member A | ||||||
Synonyms | |||||||
Species | Mus musculus | ||||||
Ensembl Protein | ENSMUSP00000020062 | ||||||
InnateDB Gene | IDBG-150347 (Gprc6a) | ||||||
Protein Structure | |||||||
UniProt Annotation | |||||||
Function | Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids. {ECO:0000269PubMed:15576628, ECO:0000269PubMed:16199532, ECO:0000269PubMed:19050760, ECO:0000269PubMed:20947496}. | ||||||
Subcellular Localization | Cell membrane {ECO:0000269PubMed:15816861}; Multi-pass membrane protein {ECO:0000269PubMed:15816861}. | ||||||
Disease Associations | |||||||
Tissue Specificity | Expressed at high level in liver, lung, spleen and heart. Expressed at lower level in kidney, skeletal muscle and brain. Expressed in E7, E11, E15 and E17 embryos. {ECO:0000269PubMed:15816861, ECO:0000269PubMed:16199532}. | ||||||
Comments | |||||||
Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||
PDB ID | MGI:2429498 | ||||||
InterPro |
IPR000337
GPCR, family 3 IPR001828 Extracellular ligand-binding receptor IPR004073 GPCR, family 3, vomeronasal receptor, type 2 IPR011500 GPCR, family 3, nine cysteines domain IPR017978 GPCR, family 3, C-terminal IPR028082 Periplasmic binding protein-like I |
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PFAM |
PF01094
PF07562 PF00003 |
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PRINTS |
PR00248
PR01535 |
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PIRSF | |||||||
SMART | |||||||
TIGRFAMs | |||||||
Post-translational Modifications | |||||||
Modification | |||||||
Cross-References | |||||||
SwissProt | Q8K4Z6 | ||||||
PhosphoSite | PhosphoSite- | ||||||
TrEMBL | |||||||
UniProt Splice Variant | |||||||
Entrez Gene | 210198 | ||||||
UniGene | Mm.221031 | ||||||
RefSeq | NP_694711 | ||||||
MGI ID | |||||||
MGI Symbol | Gprc6a | ||||||
OMIM | |||||||
CCDS | CCDS23834 | ||||||
HPRD | |||||||
IMGT | |||||||
EMBL | AY101365 AY735399 AY735400 AY735401 BC108998 | ||||||
GenPept | AAI08999 AAM22280 AAW68012 AAW68013 AAW68014 | ||||||