Version 5.4
Mus musculus Protein: Lxn
Summary
InnateDB Protein IDBP-150381.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lxn
Protein Name latexin
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000060732
InnateDB Gene IDBG-150379 (Lxn)
Protein Structure
UniProt Annotation
Function Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4 (By similarity). May play a role in inflammation. {ECO:0000250, ECO:0000269PubMed:15698574}.
Subcellular Localization Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity Highly enriched in macrophages. {ECO:0000269PubMed:15698574}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008191 metalloendopeptidase inhibitor activity
GO:0008201 heparin binding
Biological Process
GO:0006954 inflammatory response
GO:0010951 negative regulation of endopeptidase activity
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:107633
InterPro IPR009684 Proteinase inhibitor I47, latexin
PFAM PF06907
PRINTS
PIRSF PIRSF011132
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P70202
PhosphoSite PhosphoSite-P70202
TrEMBL Q14BZ3
UniProt Splice Variant
Entrez Gene 17035
UniGene Mm.2632
RefSeq NP_058033
MGI ID 1WNH
MGI Symbol Lxn
OMIM
CCDS CCDS17397
HPRD
IMGT
EMBL AK032170 AK149981 BC115521 BC115522 CH466547 D88769
GenPept AAI15522 AAI15523 BAA13700 BAC27739 BAE29211 EDL15519

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca