InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bre

Summary

InnateDB Protein

IDBP-150395.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bre

Protein Name

brain and reproductive organ-expressed protein

Synonyms

6030405P19Rik; AI429776; B830038C02Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069133

InnateDB Gene

IDBG-150391 (Bre)

Protein Structure

UniProt Annotation

Function

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin (By similarity). May regulate TNF-alpha signaling through its interactions with TNFRSF1A. {ECO:0000250, ECO:0000269PubMed:9737713}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Localizes at sites of DNA damage at double- strand breaks (DSBs). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain, heart, kidney, liver, lung, testis, germinal center B-cells and various mouse cell lines. {ECO:0000269PubMed:11676476, ECO:0000269PubMed:14565866}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0031593	polyubiquitin binding

Biological Process

GO:0006302	double-strand break repair
GO:0006915	apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0010212	response to ionizing radiation
GO:0016568	chromatin modification
GO:0031572	G2 DNA damage checkpoint
GO:0045739	positive regulation of DNA repair