InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Esam

Summary

InnateDB Protein

IDBP-150413.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Esam

Protein Name

endothelial cell-specific adhesion molecule

Synonyms

2310008D05Rik; Esam1; W117m;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002011

InnateDB Gene

IDBG-150411 (Esam)

Protein Structure

UniProt Annotation

Function

Can mediate aggregation most likely through a homophilic molecular interaction. {ECO:0000269PubMed:11279107, ECO:0000269PubMed:11847224}.

Subcellular Localization

Cell junction, adherens junction {ECO:0000305}. Cell junction, tight junction {ECO:0000305}. Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in the heart and lung. Weakly expressed in the kidney and skin. Expression is restricted to the vascular endothelial cells. Expressed in the kidney, heart and tongue (at protein level). Also expressed on megakaryocytes and activated platelets. {ECO:0000269PubMed:11279107, ECO:0000269PubMed:11847224}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007156	homophilic cell adhesion
GO:0016337	single organismal cell-cell adhesion
GO:0016338	calcium-independent cell-cell adhesion

Cellular Component

GO:0005886	plasma membrane
GO:0005912	adherens junction
GO:0005923	tight junction
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome