Version 5.4
Mus musculus Protein: Telo2
Summary
InnateDB Protein IDBP-150567.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Telo2
Protein Name TEL2, telomere maintenance 2, homolog (S. cerevisiae)
Synonyms 1200003M09Rik; AI415602; mKIAA0683; Tel2;
Species Mus musculus
Ensembl Protein ENSMUSP00000024987
InnateDB Gene IDBG-150565 (Telo2)
Protein Structure
UniProt Annotation
Function Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome, telomere {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0032403 protein complex binding
GO:0032947 protein complex scaffold
Biological Process
GO:0032006 regulation of TOR signaling
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0031931 TORC1 complex
GO:0031932 TORC2 complex
Protein Structure and Domains
PDB ID MGI:1918968
InterPro IPR019337 Telomere length regulation protein, conserved domain
PFAM PF10193
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DC40
PhosphoSite PhosphoSite-Q9DC40
TrEMBL
UniProt Splice Variant
Entrez Gene 71718
UniGene
RefSeq NP_082156
MGI ID
MGI Symbol Telo2
OMIM
CCDS CCDS28507
HPRD
IMGT
EMBL AK004582 AK028658 AK045321 AK143827 AK146963 AK154727 AY491413 BC011077
GenPept AAH11077 AAS21644 BAB23388 BAC26051 BAC32309 BAE25556 BAE27569 BAE32791

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca