InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ostn

Summary

InnateDB Protein

IDBP-150587.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ostn

Protein Name

osteocrin

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000067539

InnateDB Gene

IDBG-150585 (Ostn)

Protein Structure

UniProt Annotation

Function

Appears to modulate osteoblastic differentiation. Could also function as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in skeletal muscle and to a much lesser extent in bone, brown adipose tissue, spleen and testis. {ECO:0000269PubMed:14523025, ECO:0000269PubMed:15044443}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity

Biological Process

GO:0001503	ossification
GO:0003416	endochondral bone growth
GO:0007166	cell surface receptor signaling pathway
GO:0030154	cell differentiation
GO:0030500	regulation of bone mineralization
GO:0030828	positive regulation of cGMP biosynthetic process
GO:0045668	negative regulation of osteoblast differentiation
GO:0046325	negative regulation of glucose import