InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hspa2

Summary

InnateDB Protein

IDBP-150620.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hspa2

Protein Name

heat shock protein 2

Synonyms

70kDa; Hsp70-2; HSP70.2; HSP70A2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000079306

InnateDB Gene

IDBG-150618 (Hspa2)

Protein Structure

UniProt Annotation

Function

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed within the prinicipal peice and midpiece of sperm tail (at protein level). {ECO:0000269PubMed:23055941}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019899	enzyme binding
GO:0051082	unfolded protein binding
GO:0051861	glycolipid binding

Biological Process

GO:0000902	cell morphogenesis
GO:0001934	positive regulation of protein phosphorylation
GO:0006950	response to stress
GO:0007140	male meiosis
GO:0007141	male meiosis I
GO:0007286	spermatid development
GO:0031662	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle
GO:0042026	protein refolding
GO:0070194	synaptonemal complex disassembly
GO:0090084	negative regulation of inclusion body assembly

Cellular Component

GO:0000795	synaptonemal complex
GO:0001673	male germ cell nucleus
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0009986	cell surface
GO:0016020	membrane
GO:0036128	CatSper complex
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

MGI:96243

InterPro

IPR004753 Cell shape determining protein MreB/Mrl
IPR013126 Heat shock protein 70 family
IPR029047 Heat shock protein 70kD, peptide-binding domain
IPR029048 Heat shock protein 70kD, C-terminal domain

PFAM

PF06723
PF00012

PRINTS

PR01652
PR00301

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P17156