Version 5.4
Mus musculus Protein: Gulp1
Summary
InnateDB Protein IDBP-150643.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gulp1
Protein Name GULP, engulfment adaptor PTB domain containing 1
Synonyms 3110030A04Rik; 5730529O06Rik; CED-6; Ced6; GULP; Gulp-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000074115
InnateDB Gene IDBG-150641 (Gulp1)
Protein Structure
UniProt Annotation
Function Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization of various LRP1 ligands, such as PSAP (By similarity). May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Increases cellular levels of GTP-bound ARF6. {ECO:0000250, ECO:0000269PubMed:17398097}.
Subcellular Localization Cytoplasm {ECO:0000250}. Note=May associate with the cytoplasmic side of the plasma membrane and early endosomes. {ECO:0000250}.
Disease Associations
Tissue Specificity Detected throughout the brain, particularly in Purkinje cells, hippocampal and cortical neurons (at protein level). {ECO:0000269PubMed:17007823}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006869 lipid transport
GO:0006911 phagocytosis, engulfment
GO:0006915 apoptotic process
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1920407
InterPro IPR006020 PTB/PI domain
IPR013625 Tensin phosphotyrosine-binding domain
PFAM PF00640
PF14719
PF08416
PRINTS
PIRSF
SMART SM00462
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K2A1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 70676
UniGene Mm.466048
RefSeq NP_082726
MGI ID
MGI Symbol Gulp1
OMIM
CCDS CCDS48250
HPRD
IMGT
EMBL AK014093 AK017798 BC032154
GenPept AAH32154 BAB29151 BAB30939

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca