Version 5.4
Mus musculus Protein: Plb1
Summary
InnateDB Protein IDBP-150748.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plb1
Protein Name phospholipase B1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000098927
InnateDB Gene IDBG-150740 (Plb1)
Protein Structure
UniProt Annotation
Function Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids (By similarity). {ECO:0000250}.
Subcellular Localization Apical cell membrane {ECO:0000250}; Single- pass type I membrane protein {ECO:0000250}. Note=Present in the intestinal brush border membranes. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004622 lysophospholipase activity
GO:0004623 phospholipase A2 activity
GO:0016788 hydrolase activity, acting on ester bonds
Biological Process
GO:0006629 lipid metabolic process
GO:0016042 lipid catabolic process
Cellular Component
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
Protein Structure and Domains
PDB ID MGI:1922406
InterPro IPR001087 Lipase, GDSL
PFAM PF00657
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3TTY0
PhosphoSite PhosphoSite-Q3TTY0
TrEMBL Q8K255
UniProt Splice Variant
Entrez Gene 665270
UniGene Mm.160067
RefSeq NP_742159
MGI ID
MGI Symbol Plb1
OMIM
CCDS CCDS39060
HPRD
IMGT
EMBL AC102372 AC111030 AK015993 AK161095 BC033606 BC119077
GenPept AAH33606 AAI19078 BAB30072 BAE36193

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca