InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spa17

Summary

InnateDB Protein

IDBP-150769.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spa17

Protein Name

sperm autoantigenic protein 17

Synonyms

Sp17;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002013

InnateDB Gene

IDBG-150767 (Spa17)

Protein Structure

UniProt Annotation

Function

Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Testis- and sperm-specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001539	cilium or flagellum-dependent cell motility
GO:0007339	binding of sperm to zona pellucida

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane
GO:0031514	motile cilium
GO:0072372	primary cilium

Protein Structure and Domains

PDB ID

MGI:1333778

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR003117 Dimerization-anchoring domain of cAMP-dependent protein kinase, regulatory subunit
IPR012105 Sperm surface protein Sp17

PFAM

PF00612
PF02197

PRINTS

PIRSF

PIRSF016533

SMART

SM00015
SM00394

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt