InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNFRSF19

Summary

InnateDB Protein

IDBP-15081.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFRSF19

Protein Name

tumor necrosis factor receptor superfamily, member 19

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000371698

InnateDB Gene

IDBG-15073 (TNFRSF19)

Protein Structure

UniProt Annotation

Function

Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005031	tumor necrosis factor-activated receptor activity
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0007254	JNK cascade
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling