InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdx1

Summary

InnateDB Protein

IDBP-150824.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdx1

Protein Name

caudal type homeobox 1

Synonyms

Cdx; Cdx-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025521

InnateDB Gene

IDBG-150822 (Cdx1)

Protein Structure

UniProt Annotation

Function

Could play a role in the terminal differentiation of the intestine.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Intestinal epithelium.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	5 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0007389	pattern specification process
GO:0009952	anterior/posterior pattern specification
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060349	bone morphogenesis

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:88360

InterPro

IPR000047 Helix-turn-helix motif
IPR001356 Homeobox domain
IPR006820 Caudal-like activation domain
IPR009057 Homeodomain-like
IPR020479 Homeodomain, metazoa

PFAM

PF00046
PF04731

PRINTS

PR00031
PR00024

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt