InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pcm1

Summary

InnateDB Protein

IDBP-150839.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pcm1

Protein Name

pericentriolar material 1

Synonyms

2600002H09Rik; 9430077F19Rik; C030044G17Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039709

InnateDB Gene

IDBG-150837 (Pcm1)

Protein Structure

UniProt Annotation

Function

Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins probably including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Probably involved in the biogenesis of cilia. {ECO:0000269PubMed:12112146}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Note=Recruitement to the centrosome requires microtubules and dynein. Displaced from centriolar satellites and centrosome in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, in a process that requires p38 MAP kinase signaling (By similarity). The majority of the protein dissociates from the centrosome during metaphase and subsequently localizes to the cleavage site in telophase. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the hippocampus and dentate gyrus, the columnar epithelial cells of bronchioles, the olfactory epithelium, the pericardium and the inner segment of the retina. {ECO:0000269PubMed:15107855}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0022027	interkinetic nuclear migration
GO:0031122	cytoplasmic microtubule organization
GO:0034453	microtubule anchoring
GO:0034454	microtubule anchoring at centrosome
GO:0035735	intraciliary transport involved in cilium morphogenesis
GO:0042384	cilium assembly
GO:0050768	negative regulation of neurogenesis
GO:0051297	centrosome organization
GO:0071539	protein localization to centrosome
GO:0090316	positive regulation of intracellular protein transport
GO:0097150	neuronal stem cell maintenance

Cellular Component

GO:0000242	pericentriolar material
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0016020	membrane
GO:0031965	nuclear membrane
GO:0034451	centriolar satellite
GO:0036064	ciliary basal body
GO:0043234	protein complex