InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pcsk5

Summary

InnateDB Protein

IDBP-150934.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pcsk5

Protein Name

proprotein convertase subtilisin/kexin type 5

Synonyms

b2b1549Clo; b2b585Clo; PC5; PC5/6A; PC5A; PC6; SPC6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050272

InnateDB Gene

IDBG-150930 (Pcsk5)

Protein Structure

UniProt Annotation

Function

Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors (By similarity). {ECO:0000250}.

Subcellular Localization

Isoform PC5A: Secreted. Note=Secreted through the regulated secretory pathway.Isoform PC5B: Endomembrane system; Single- pass type I membrane protein. Note=Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes.

Disease Associations

Tissue Specificity

PC5A is expressed in most tissues but is most abundant in the intestine and adrenals. PC5B is expressed in the intestine, adrenals and lung but not in the brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0042277	peptide binding

Biological Process

GO:0001822	kidney development
GO:0002001	renin secretion into blood stream
GO:0006465	signal peptide processing
GO:0006508	proteolysis
GO:0007507	heart development
GO:0007566	embryo implantation
GO:0009952	anterior/posterior pattern specification
GO:0016485	protein processing
GO:0016486	peptide hormone processing
GO:0019058	viral life cycle
GO:0030323	respiratory tube development
GO:0035108	limb morphogenesis
GO:0042089	cytokine biosynthetic process
GO:0043043	peptide biosynthetic process
GO:0048566	embryonic digestive tract development
GO:0048706	embryonic skeletal system development

Cellular Component

GO:0005615	extracellular space
GO:0005788	endoplasmic reticulum lumen
GO:0005794	Golgi apparatus
GO:0016021	integral component of membrane
GO:0030141	secretory granule

Protein Structure and Domains

PDB ID

MGI:97515

InterPro

IPR000209 Peptidase S8/S53 domain
IPR000742 Epidermal growth factor-like domain
IPR002884 Proprotein convertase, P
IPR006212 Furin-like repeat
IPR008979 Galactose-binding domain-like
IPR009020 Proteinase inhibitor, propeptide
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR010909 PLAC
IPR015500 Peptidase S8, subtilisin-related

PFAM

PF00082
PF00008
PF01483
PF08686

PRINTS

PR00723

PIRSF

SMART

SM00181
SM00261

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt