InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptgr1

Summary

InnateDB Protein

IDBP-150973.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptgr1

Protein Name

prostaglandin reductase 1

Synonyms

2510002C21Rik; Ltb4dh; Zadh3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030069

InnateDB Gene

IDBG-150971 (Ptgr1)

Protein Structure

UniProt Annotation

Function

Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12- oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0032440	2-alkenal reductase [NAD(P)] activity
GO:0036132	13-prostaglandin reductase activity
GO:0047522	15-oxoprostaglandin 13-oxidase activity

Biological Process

GO:0006693	prostaglandin metabolic process
GO:0009636	response to toxic substance
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1914353

InterPro

IPR011032 GroES (chaperonin 10)-like
IPR013149 Alcohol dehydrogenase, C-terminal
IPR014190 Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase
IPR020843 Polyketide synthase, enoylreductase

PFAM

PF00107

PRINTS

PIRSF

SMART

SM00829

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91YR9