InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Smc4

Summary

InnateDB Protein

IDBP-151133.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smc4

Protein Name

structural maintenance of chromosomes 4

Synonyms

2500002A22Rik; C79747; SMC-4; Smc4l1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047872

InnateDB Gene

IDBG-151131 (Smc4)

Protein Structure

UniProt Annotation

Function

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Chromosome {ECO:0000250}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0007076	mitotic chromosome condensation
GO:0010032	meiotic chromosome condensation
GO:0045132	meiotic chromosome segregation
GO:0051276	chromosome organization
GO:0051383	kinetochore organization