InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nol8

Summary

InnateDB Protein

IDBP-151244.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nol8

Protein Name

nucleolar protein 8

Synonyms

4921532D18Rik; 5730412B09Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021824

InnateDB Gene

IDBG-151242 (Nol8)

Protein Structure

UniProt Annotation

Function

Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}. Note=Localizes in the nucleolar-organizing region during ribosome biogenesis. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding