InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trpm6

Summary

InnateDB Protein

IDBP-151343.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trpm6

Protein Name

transient receptor potential cation channel, subfamily M, member 6

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037443

InnateDB Gene

IDBG-151341 (Trpm6)

Protein Structure

UniProt Annotation

Function

Essential ion channel and kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004674	protein serine/threonine kinase activity
GO:0005216	ion channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006811	ion transport
GO:0009636	response to toxic substance
GO:0030001	metal ion transport
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport