Version 5.4
Homo sapiens Protein: ADAT3
Summary
InnateDB Protein IDBP-15150.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAT3
Protein Name adenosine deaminase, tRNA-specific 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000332448
InnateDB Gene IDBG-239705 (ADAT3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations Mental retardation, autosomal recessive 36 (MRT36) [MIM:615286]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT36 is often associated with esotropia and failure to thrive. Other more variable features included microcephaly, hypotonia, and mild brain abnormalities on MRI, such as dilated ventricles or delayed myelination. {ECO:0000269PubMed:23620220}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
Biological Process
GO:0008033 tRNA processing
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR002125 CMP/dCMP deaminase, zinc-binding
IPR016193 Cytidine deaminase-like
PFAM PF00383
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96EY9
PhosphoSite PhosphoSite-Q96EY9
TrEMBL D6W601
UniProt Splice Variant
Entrez Gene 113179
UniGene
RefSeq NP_612431
HUGO HGNC:25151
OMIM 615302
CCDS CCDS12076
HPRD 14000
IMGT
EMBL AC012615 BC011824 CH471139
GenPept AAH11824 EAW69434 EAW69436 EAW69438

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca