InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Col5a1

Summary

InnateDB Protein

IDBP-151518.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Col5a1

Protein Name

collagen, type V, alpha 1

Synonyms

AI413331;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028280

InnateDB Gene

IDBG-151514 (Col5a1)

Protein Structure

UniProt Annotation

Function

Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (By similarity). Transcriptionally activated by CEBPZ, which recognizes a CCAAT-like motif, CAAAT in the COL5A1 promoter. {ECO:0000250, ECO:0000269PubMed:15246108}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000255PROSITE-ProRule:PRU00793}.

Disease Associations

Tissue Specificity

Expressed in limbs, vertebrae, heart, brain, liver, intestine, tongue, tail, skin, calvaria, lung and kidney of E18 embryos. {ECO:0000269PubMed:9582436}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0043394	proteoglycan binding
GO:0048407	platelet-derived growth factor binding

Biological Process

GO:0001568	blood vessel development
GO:0003007	heart morphogenesis
GO:0007155	cell adhesion
GO:0016477	cell migration
GO:0030199	collagen fibril organization
GO:0032964	collagen biosynthetic process
GO:0035313	wound healing, spreading of epidermal cells
GO:0035989	tendon development
GO:0043206	extracellular fibril organization
GO:0043588	skin development
GO:0045112	integrin biosynthetic process
GO:0048592	eye morphogenesis
GO:0051128	regulation of cellular component organization

Cellular Component

GO:0005581	collagen trimer
GO:0005588	collagen type V
GO:0005604	basement membrane
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:88457

InterPro

IPR000885 Fibrillar collagen, C-terminal
IPR001791 Laminin G domain
IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
IPR008160 Collagen triple helix repeat
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF01410
PF00054
PF02210
PF00147
PF01391

PRINTS

PIRSF

SMART

SM00038
SM00210
SM00282
SM00186

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O88207