Version 5.4
Mus musculus Protein: Naprt1
Summary
InnateDB Protein IDBP-151536.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Naprt1
Protein Name nicotinate phosphoribosyltransferase domain containing 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000023237
InnateDB Gene IDBG-151534 (Naprt1)
Protein Structure
UniProt Annotation
Function Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells (By similarity). {ECO:0000250}.Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP. {ECO:0000250}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}.
Disease Associations
Tissue Specificity Abundantly expressed in the small intestine, liver and kidney. {ECO:0000269PubMed:17604275}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity
GO:0004516 nicotinate phosphoribosyltransferase activity
GO:0016874 ligase activity
Biological Process
GO:0006979 response to oxidative stress
GO:0009435 NAD biosynthetic process
GO:0019358 nicotinate nucleotide salvage
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2442664
InterPro IPR002638 Quinolinate phosphoribosyl transferase, C-terminal
IPR006405 Nicotinate phosphoribosyltransferase pncB type
IPR007229 Nicotinate phosphoribosyltransferase family
PFAM PF01729
PF04095
PRINTS
PIRSF PIRSF000484
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CC86
PhosphoSite PhosphoSite-Q8CC86
TrEMBL
UniProt Splice Variant
Entrez Gene 223646
UniGene Mm.288368
RefSeq NP_766195
MGI ID
MGI Symbol Naprt1
OMIM
CCDS CCDS27552
HPRD
IMGT
EMBL AK033661 AK049157 AK159127 AK170518 AY214331 BC058800
GenPept AAH58800 AAP69609 BAC28414 BAC33575 BAE34841 BAE41854

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca