InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fut8

Summary

InnateDB Protein

IDBP-151555.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fut8

Protein Name

fucosyltransferase 8

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000054530

InnateDB Gene

IDBG-151551 (Fut8)

Protein Structure

UniProt Annotation

Function

Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. {ECO:0000250}.

Subcellular Localization

Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Membrane-bound form in trans cisternae of Golgi. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008424	glycoprotein 6-alpha-L-fucosyltransferase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0017124	SH3 domain binding
GO:0046921	alpha-(1->6)-fucosyltransferase activity

Biological Process

GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007229	integrin-mediated signaling pathway
GO:0007585	respiratory gaseous exchange
GO:0016477	cell migration
GO:0018279	protein N-linked glycosylation via asparagine
GO:0033578	protein glycosylation in Golgi
GO:0036065	fucosylation
GO:0036071	N-glycan fucosylation
GO:0043112	receptor metabolic process
GO:0046368	GDP-L-fucose metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032580	Golgi cisterna membrane
GO:0070062	extracellular vesicular exosome