Version 5.4
Mus musculus Protein: Prss28
Summary
InnateDB Protein IDBP-151567.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prss28
Protein Name protease, serine, 28
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000015267
InnateDB Gene IDBG-151565 (Prss28)
Protein Structure
UniProt Annotation
Function Involved in embryo hatching and implantation. {ECO:0000269PubMed:11425330, ECO:0000269PubMed:15293213, ECO:0000269PubMed:17156484}.
Subcellular Localization Secreted {ECO:0000305}. Note=Secretion into the glandular and uterine lumen may occur as a consequence of progesterone-induced epithelial differentiation. {ECO:0000269PubMed:12112596, ECO:0000269PubMed:15349836}.
Disease Associations
Tissue Specificity Expressed in embryos throughout the preimplantation period, during blastocyst hatching and embryo outgrowth. Found in uterus especially in glandular epithelium. {ECO:0000269PubMed:11425330, ECO:0000269PubMed:12112596, ECO:0000269PubMed:15293213}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007566 embryo implantation
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID MGI:2149951
InterPro IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
PFAM PF00089
PRINTS PR00722
PIRSF
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q924N9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 114661
UniGene Mm.207081
RefSeq NP_444489
MGI ID
MGI Symbol Prss28
OMIM
CCDS CCDS28515
HPRD
IMGT
EMBL AF184895 AK144498 AY520825 BC119386 BC119388
GenPept AAI19387 AAI19389 AAK84171 AAT66743 BAE25918

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca