InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hes1

Summary

InnateDB Protein

IDBP-151890.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hes1

Protein Name

hairy and enhancer of split 1 (Drosophila)

Synonyms

bHLHb39; Hry;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023171

InnateDB Gene

IDBG-151888 (Hes1)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross- link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed at high levels in undifferentiated neural precursor cells, but the level of expression decreases as neural differentiation proceeds.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	5 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity
GO:0071820	N-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0001889	liver development
GO:0003143	embryonic heart tube morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0003266	regulation of secondary heart field cardioblast proliferation
GO:0003281	ventricular septum development
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006461	protein complex assembly
GO:0007155	cell adhesion
GO:0007219	Notch signaling pathway
GO:0007224	smoothened signaling pathway
GO:0007262	STAT protein import into nucleus
GO:0007389	pattern specification process
GO:0008284	positive regulation of cell proliferation
GO:0016477	cell migration
GO:0021537	telencephalon development
GO:0021555	midbrain-hindbrain boundary morphogenesis
GO:0021557	oculomotor nerve development
GO:0021558	trochlear nerve development
GO:0021575	hindbrain morphogenesis
GO:0021861	forebrain radial glial cell differentiation
GO:0021915	neural tube development
GO:0021983	pituitary gland development
GO:0021984	adenohypophysis development
GO:0030324	lung development
GO:0030513	positive regulation of BMP signaling pathway
GO:0030901	midbrain development
GO:0031016	pancreas development
GO:0031018	endocrine pancreas development
GO:0035019	somatic stem cell maintenance
GO:0035909	aorta morphogenesis
GO:0035910	ascending aorta morphogenesis
GO:0042102	positive regulation of T cell proliferation
GO:0042491	auditory receptor cell differentiation
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042668	auditory receptor cell fate determination
GO:0043388	positive regulation of DNA binding
GO:0045165	cell fate commitment
GO:0045596	negative regulation of cell differentiation
GO:0045598	regulation of fat cell differentiation
GO:0045608	negative regulation of auditory receptor cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045747	positive regulation of Notch signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045977	positive regulation of mitotic cell cycle, embryonic
GO:0046331	lateral inhibition
GO:0046427	positive regulation of JAK-STAT cascade
GO:0048469	cell maturation
GO:0048505	regulation of timing of cell differentiation
GO:0048538	thymus development
GO:0048667	cell morphogenesis involved in neuron differentiation
GO:0048711	positive regulation of astrocyte differentiation
GO:0048715	negative regulation of oligodendrocyte differentiation
GO:0048844	artery morphogenesis
GO:0050767	regulation of neurogenesis
GO:0060164	regulation of timing of neuron differentiation
GO:0060253	negative regulation of glial cell proliferation
GO:0060412	ventricular septum morphogenesis
GO:0060675	ureteric bud morphogenesis
GO:0060716	labyrinthine layer blood vessel development
GO:0061009	common bile duct development
GO:0061106	negative regulation of stomach neuroendocrine cell differentiation
GO:0061309	cardiac neural crest cell development involved in outflow tract morphogenesis
GO:0061626	pharyngeal arch artery morphogenesis
GO:0072012	glomerulus vasculature development
GO:0072049	comma-shaped body morphogenesis
GO:0072050	S-shaped body morphogenesis
GO:0072141	renal interstitial cell development
GO:0072282	metanephric nephron tubule morphogenesis
GO:0090102	cochlea development
GO:0097084	vascular smooth muscle cell development
GO:0097150	neuronal stem cell maintenance
GO:2000227	negative regulation of pancreatic A cell differentiation
GO:2000737	negative regulation of stem cell differentiation
GO:2000974	negative regulation of pro-B cell differentiation
GO:2000978	negative regulation of forebrain neuron differentiation
GO:2000981	negative regulation of inner ear receptor cell differentiation