Version 5.4
Mus musculus Protein: Gbgt1
Summary
InnateDB Protein IDBP-152039.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gbgt1
Protein Name globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000028172
InnateDB Gene IDBG-152037 (Gbgt1)
Protein Structure
UniProt Annotation
Function Catalyzes the formation of Forssman glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to GalNAcb-1,3Gala-1,4Galb-1,4GlcCer (Gb4Cer). Forssman glycolipid (also called Forssman antigen; FG) probably serves for adherence of some pathogens. Conversely, it diminishes Shiga toxins susceptibility. {ECO:0000269PubMed:14573676}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016758 transferase activity, transferring hexosyl groups
GO:0046872 metal ion binding
GO:0047277 globoside alpha-N-acetylgalactosaminyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006486 protein glycosylation
GO:0030259 lipid glycosylation
Cellular Component
GO:0000139 Golgi membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2449143
InterPro IPR005076 Glycosyl transferase, family 6
IPR029044 Nucleotide-diphospho-sugar transferases
PFAM PF03414
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VI38
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 227671
UniGene Mm.484270
RefSeq XP_006497983
MGI ID
MGI Symbol Gbgt1
OMIM
CCDS CCDS15839
HPRD
IMGT
EMBL AB084789 AF292399 AL772249 BC106831
GenPept AAI06832 AAL37034 BAC23060 CAM24089

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca