InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: F11

Summary

InnateDB Protein

IDBP-152057.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

F11

Protein Name

coagulation factor XI

Synonyms

1600027G01Rik; AI503996; Cf11; FXI;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034064

InnateDB Gene

IDBG-152055 (F11)

Protein Structure

UniProt Annotation

Function

Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0070009	serine-type aminopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0030193	regulation of blood coagulation
GO:0031639	plasminogen activation
GO:0045087	innate immune response (InnateDB)
GO:0051919	positive regulation of fibrinolysis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:99481

InterPro

IPR000177 Apple domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR003014 PAN-1 domain
IPR003609 Apple-like
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR015420 Peptidase S1A, nudel

PFAM

PF00089
PF00024
PF09342

PRINTS

PR00005
PR00722

PIRSF

SMART

SM00223
SM00020
SM00473

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt