InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp6v1d

Summary

InnateDB Protein

IDBP-152075.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp6v1d

Protein Name

ATPase, H+ transporting, lysosomal V1 subunit D

Synonyms

1110004P10Rik; Atp6m; VATD; Vma8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021536

InnateDB Gene

IDBG-152073 (Atp6v1d)

Protein Structure

UniProt Annotation

Function

Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Localizes to centrosome and the base of the cilium. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0015992	proton transport
GO:0042384	cilium assembly
GO:0055085	transmembrane transport
GO:0061512	protein localization to cilium

Cellular Component

GO:0005765	lysosomal membrane
GO:0005813	centrosome
GO:0005929	cilium
GO:0016020	membrane
GO:0016471	vacuolar proton-transporting V-type ATPase complex
GO:0070062	extracellular vesicular exosome