InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mapk15

Summary

InnateDB Protein

IDBP-152081.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mapk15

Protein Name

mitogen-activated protein kinase 15

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000087098

InnateDB Gene

IDBG-152079 (Mapk15)

Protein Structure

UniProt Annotation

Function

Constitutively active kinase which may function as a negative regulator of cell growth. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004707	MAP kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000165	MAPK cascade
GO:0001934	positive regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0008156	negative regulation of DNA replication
GO:0031398	positive regulation of protein ubiquitination
GO:0032355	response to estradiol
GO:0045732	positive regulation of protein catabolic process
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:2652894

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt