InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ralgds

Summary

InnateDB Protein

IDBP-152125.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ralgds

Protein Name

ral guanine nucleotide dissociation stimulator

Synonyms

Gnds; mKIAA1308; Rgds;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028170

InnateDB Gene

IDBG-152123 (Ralgds)

Protein Structure

UniProt Annotation

Function

Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0043087	regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622

intracellular

Protein Structure and Domains

PDB ID

MGI:107485

InterPro

IPR000159 Ras-association
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895 Guanine-nucleotide dissociation stimulator CDC25
IPR023578 Ras guanine nucleotide exchange factor, domain
IPR029071 Ubiquitin-related domain

PFAM

PF00788
PF00618
PF00617

PRINTS

PIRSF

SMART

SM00314
SM00229
SM00147

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q03385