InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nxnl2

Summary

InnateDB Protein

IDBP-152153.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nxnl2

Protein Name

nucleoredoxin-like 2

Synonyms

4930519N16Rik; Rdcvf2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021828

InnateDB Gene

IDBG-152151 (Nxnl2)

Protein Structure

UniProt Annotation

Function

May be involved in the maintenance of both the function and the viability of sensory neurons, including photoreceptors and olfactory neurons. In the retina, isoform 1 may be required for rod function and isoform 2 for cone viability and function. {ECO:0000269PubMed:22343139}.

Subcellular Localization

Disease Associations

Tissue Specificity

Both isoforms are expressed in retina, in the photoreceptor layer, and throughout the olfactory sensory neuron layer of the nasal epithelium, in neurons. Also expressed at low levels in brain and testis. {ECO:0000269PubMed:17764561, ECO:0000269PubMed:22343139}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0007601	visual perception
GO:0007608	sensory perception of smell

Cellular Component

GO:0005575

cellular_component

Protein Structure and Domains

PDB ID

MGI:1922374

InterPro

IPR012336 Thioredoxin-like fold

PFAM

PF13098
PF13192
PF13462
PF13905

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D531

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

75124

UniGene

RefSeq

NP_083449

MGI ID

MGI Symbol

Nxnl2

OMIM

CCDS

CCDS26511

HPRD

IMGT

EMBL

AK015847 BC016199 BC038905

GenPept

AAH38905 BAB29999