InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: S1pr3

Summary

InnateDB Protein

IDBP-152201.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S1pr3

Protein Name

sphingosine-1-phosphate receptor 3

Synonyms

AI132464; Edg3; Lpb3; S1p3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000085293

InnateDB Gene

IDBG-152199 (S1pr3)

Protein Structure

UniProt Annotation

Function

Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Most abundant in heart, lung, kidney and spleen; low but detectable in brain, thymus, muscle and testis; and nearly undetectable in liver, stomach, and intestine. Expressed in embryonic lung from embryonic day 14-18. Also abundantly detected in embryonic nasal cartilage, sphenoid bone, vena cava, Meckel's cartilage/incisor teeth, genital tubercle and bladder. {ECO:0000269PubMed:9931453}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005178	integrin binding
GO:0038036	sphingosine-1-phosphate receptor activity

Biological Process

GO:0001816	cytokine production
GO:0003376	sphingosine-1-phosphate signaling pathway
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0032651	regulation of interleukin-1 beta production
GO:1903141	negative regulation of establishment of endothelial barrier

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1339365

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000987 EDG-1 sphingosine 1-phosphate receptor
IPR004061 Sphingosine 1-phosphate receptor
IPR004062 EDG-3 sphingosine 1-phosphate receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00642
PR01523
PR01524

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Z0U9