Version 5.4
Mus musculus Protein: Shc3
Summary
InnateDB Protein IDBP-152238.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Shc3
Protein Name src homology 2 domain-containing transforming protein C3
Synonyms N-Shc; Rai; ShcC;
Species Mus musculus
Ensembl Protein ENSMUSP00000021898
InnateDB Gene IDBG-152236 (Shc3)
Protein Structure
UniProt Annotation
Function Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Predominantly expressed in the adult brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007611 learning or memory
GO:0035249 synaptic transmission, glutamatergic
GO:0035556 intracellular signal transduction
Cellular Component
Protein Structure and Domains
PDB ID MGI:106179
InterPro IPR000980 SH2 domain
IPR006019 Phosphotyrosine interaction domain, Shc-like
IPR006020 PTB/PI domain
PFAM PF00017
PF14633
PF00640
PF14719
PRINTS PR00401
PR00629
PIRSF
SMART SM00252
SM00462
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q61120
PhosphoSite PhosphoSite-Q61120
TrEMBL
UniProt Splice Variant
Entrez Gene 20418
UniGene
RefSeq NP_033193
MGI ID
MGI Symbol Shc3
OMIM
CCDS CCDS49265
HPRD
IMGT
EMBL BC103612 BC105644 BC105645 U46854
GenPept AAC52508 AAI03613 AAI05645 AAI05646

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca