Version 5.4
Mus musculus Protein: Grpel2
Summary
InnateDB Protein IDBP-152241.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Grpel2
Protein Name GrpE-like 2, mitochondrial
Synonyms mt-GrpE#2; mt-Grpel2;
Species Mus musculus
Ensembl Protein ENSMUSP00000053440
InnateDB Gene IDBG-152239 (Grpel2)
Protein Structure
UniProt Annotation
Function Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70.
Subcellular Localization Mitochondrion matrix.
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000774 adenyl-nucleotide exchange factor activity
GO:0042803 protein homodimerization activity
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
Biological Process
GO:0006457 protein folding
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID MGI:1334416
InterPro IPR000740 GrpE nucleotide exchange factor
IPR009012 GrpE nucleotide exchange factor, head
PFAM PF01025
PRINTS PR00773
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88396
PhosphoSite PhosphoSite-
TrEMBL Q0VB85
UniProt Splice Variant
Entrez Gene 17714
UniGene Mm.401123
RefSeq NP_067271
MGI ID
MGI Symbol Grpel2
OMIM
CCDS CCDS29288
HPRD
IMGT
EMBL AF041060 AK003011 AK012634 AK082983 AK145493 BC068232 BC120747 CH466528
GenPept AAC31364 AAH68232 AAI20748 BAB22511 BAB28371 BAC38720 BAE26470 EDL09759

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca