Version 5.4
Mus musculus Protein: Sstr5
Summary
InnateDB Protein IDBP-152274.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sstr5
Protein Name somatostatin receptor 5
Synonyms Smstr5; sst5;
Species Mus musculus
Ensembl Protein ENSMUSP00000051085
InnateDB Gene IDBG-152272 (Sstr5)
Protein Structure
UniProt Annotation
Function Receptor for somatostatin-28. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.
Subcellular Localization Cell membrane {ECO:0000269PubMed:21820437}; Multi-pass membrane protein {ECO:0000269PubMed:21820437}.
Disease Associations
Tissue Specificity Expressed in adult brain but not in liver, heart, spleen, or kidney. {ECO:0000269PubMed:9300821}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004994 somatostatin receptor activity
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0032467 positive regulation of cytokinesis
GO:0038170 somatostatin signaling pathway
GO:0042593 glucose homeostasis
GO:0050796 regulation of insulin secretion
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:894282
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000586 Somatostatin receptor family
IPR000611 Neuropeptide Y receptor family
IPR001184 Somatostatin receptor 5
IPR001418 Opioid receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019426 7TM GPCR, serpentine receptor class v (Srv)
IPR019427 7TM GPCR, serpentine receptor class w (Srw)
IPR019430 7TM GPCR, serpentine receptor class x (Srx)
PFAM PF00001
PF10320
PF10323
PF10324
PF10328
PRINTS PR00237
PR00246
PR01012
PR00591
PR00384
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O08858
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 20609
UniGene Mm.489569
RefSeq NP_035555
MGI ID
MGI Symbol Sstr5
OMIM
CCDS CCDS28520
HPRD
IMGT
EMBL AC131323 AF004740 AF030441 AF035777 AK133609 AK133767 BC145943 BC150805 U82697
GenPept AAB61418 AAB86492 AAB88302 AAC53353 AAI45944 AAI50806 BAE21747 BAE21829

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca