Version 5.4
Mus musculus Protein: Plek2
Summary
InnateDB Protein IDBP-152277.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plek2
Protein Name pleckstrin 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000021544
InnateDB Gene IDBG-152275 (Plek2)
Protein Structure
UniProt Annotation
Function May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation. Overexpression of pleckstrin 2 causes large lamellipodia and peripheral ruffle formation.
Subcellular Localization Cell projection, lamellipodium membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton.
Disease Associations
Tissue Specificity Ubiquitous. Most abundant in the thymus, large bowel, small bowel, stomach, and prostate.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0031258 lamellipodium membrane
Protein Structure and Domains
PDB ID MGI:1351466
InterPro IPR000591 DEP domain
IPR001849 Pleckstrin homology domain
PFAM PF00610
PF00169
PRINTS
PIRSF
SMART SM00049
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WV52
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 27260
UniGene Mm.103380
RefSeq NP_038766
MGI ID 1V3F
MGI Symbol Plek2
OMIM
CCDS CCDS26004
HPRD
IMGT
EMBL AF157600 AF170564 BC028902
GenPept AAD42973 AAD46924 AAH28902

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca