InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyp4v3

Summary

InnateDB Protein

IDBP-152288.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp4v3

Protein Name

cytochrome P450, family 4, subfamily v, polypeptide 3

Synonyms

AU043077; AW111961; Cyp4v2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000092966

InnateDB Gene

IDBG-260359 (Cyp4v3)

Protein Structure

UniProt Annotation

Function

Catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12) (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding

Biological Process

GO:0010430	fatty acid omega-oxidation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005575	cellular_component
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2142763

InterPro

IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002402 Cytochrome P450, E-class, group II
IPR002403 Cytochrome P450, E-class, group IV

PFAM

PF00067

PRINTS

PR00385
PR00463
PR00464
PR00465

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9DBW0