InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hsf2

Summary

InnateDB Protein

IDBP-152302.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hsf2

Protein Name

heat shock factor 2

Synonyms

AI661205;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000078761

InnateDB Gene

IDBG-152298 (Hsf2)

Protein Structure

UniProt Annotation

Function

DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. HSF2 is expressed in a form that binds DNA constitutively but loses DNA binding by incubation at greater than 41 degrees C.

Subcellular Localization

Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth and moves to the nucleus upon activation.

Disease Associations

Tissue Specificity

Isoform alpha is expressed predominantly in testis while isoform beta is expressed predominantly in heart and brain. {ECO:0000269PubMed:7565677}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006950	response to stress
GO:0007283	spermatogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter