Version 5.4
Mus musculus Protein: Tmeff2
Summary
InnateDB Protein IDBP-152308.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmeff2
Protein Name transmembrane protein with EGF-like and two follistatin-like domains 2
Synonyms 4832418D20Rik; 7630402F16Rik; TR-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000080533
InnateDB Gene IDBG-152306 (Tmeff2)
Protein Structure
UniProt Annotation
Function May be a survival factor for hippocampal and mesencephalic neurons. The shedded form may up-regulate cell proliferation (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Widely expressed in the brain. In the olfactory bulb expressed in mitral cell, granule, and glomerular layers. In the hippocampus expressed in hippocampal cornu ammonis, pyramidal layer, dentate gyrus, and substantia nigra pars compacta. {ECO:0000269PubMed:10903839}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1861735
InterPro IPR000742 Epidermal growth factor-like domain
IPR002350 Kazal domain
PFAM PF00008
PF00050
PF07648
PRINTS
PIRSF
SMART SM00181
SM00280
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QYM9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 56363
UniGene Mm.245154
RefSeq NP_062764
MGI ID
MGI Symbol Tmeff2
OMIM
CCDS CCDS14939
HPRD
IMGT
EMBL AB017270 AB041565 AK029307 AK030053 AK076254 AK135038 BC034850
GenPept AAH34850 BAA87898 BAA95049 BAC26385 BAC26760 BAC36276 BAE22393

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca