InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zfand5

Summary

InnateDB Protein

IDBP-152383.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zfand5

Protein Name

zinc finger, AN1-type domain 5

Synonyms

2310057A04Rik; 5830475F03Rik; AA415485; Za20d2; Zfp216;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025659

InnateDB Gene

IDBG-152381 (Zfand5)

Protein Structure

UniProt Annotation

Function

Involved in protein degradation via the ubiquitin- proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4- induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. {ECO:0000269PubMed:16194934, ECO:0000269PubMed:16424905}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain, muscle, eye, and heart, lower expression in lung, kidney, and spleen, and very low expression in liver. Expressed in myoblast C2C12 cells (at protein level). {ECO:0000269PubMed:14754897, ECO:0000269PubMed:9758550}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001944	vasculature development
GO:0003016	respiratory system process
GO:0010761	fibroblast migration
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048705	skeletal system morphogenesis
GO:0048745	smooth muscle tissue development
GO:0060324	face development